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Last week, drugmaker Eli Lilly announced results from a late-stage diabetes trial showing that its daily GLP-1 pill orforglipron significantly reduced A1C (a measure of blood sugar) and body weight compared with placebo (a sham pill)

After all, pundits often describe them as miracle weight-loss drugs

Cardiovascular-Kidney-Metabolic (CKM) Syndrome , as defined by the AHA, is a systemic disorder characterized by pathophysiological interactions among metabolic risk factors (such as obesity, insulin resistance, dyslipidemia, and hypertension), chronic kidney disease (CKD), and the cardiovascular system, leading to multiorgan dysfunction and a high rate of adverse cardiovascular outcomes [145]

There are dozens of biological reasons why people struggle to lose weight